PDRN vs ESM?
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C-PDRN vs Eggshell Membrane: Which Delivers True Anti-Aging Power?
In the world of skincare, innovation moves fast. If you’ve explored K-beauty or medical aesthetics, you may have seen the buzz around PDRN — a DNA-based ingredient originally derived from salmon. More recently, C-PDRN (Cosmetic PDRN) has entered the scene, formulated in smaller hydrolyzed fragments so it can actually penetrate the skin without injections.
At the same time, there’s a rising wave of interest in eggshell membrane (ESM) — a natural, sustainable source of collagen, elastin, hyaluronic acid, and amino acids that can be used both topically and orally. At Vicky en France, we chose ESM as our hero ingredient. Here’s why.
What is C-PDRN?
- The origin: PDRN (polydeoxyribonucleotide) was first researched in the 1970s for wound healing and tissue regeneration. In clinics, it is best known through injectables that help with skin repair. Procedures usually costs thousands of dollars.
- The cosmetic form: C-PDRN is hydrolyzed into smaller fragments, making it absorbable into the skin through serums, ampoules, or creams.
- The benefits: Research suggests C-PDRN helps stimulate fibroblasts, promote cell renewal, soothe irritation, and improve skin texture and brightness. Many clinics recommend it for post-treatment recovery or stressed skin.
💡 In short: C-PDRN is a smart evolution of injectable PDRN, offering a non-invasive way to support skin renewal.
What is Eggshell Membrane (ESM)?
- The origin: Used since 16th century ancient times in traditional remedies for wound healing, modern science now extracts eggshell membrane in purified, food-safe form.
- The composition: Naturally rich in collagen types I, V, and X, elastin, hyaluronic acid, and 18 amino acids — the exact building blocks our skin and joints lose with age.
- The benefits: ESM supports skin elasticity, hydration, joint comfort, hair and nail strength. Most importantly, it works both inside and outside — edible supplements nourish from within, while topical skincare adds targeted support.
💡 In short: ESM is a whole-body longevity ingredient, rebuilding the skin matrix from the ground up.
C-PDRN vs ESM: How Do They Compare?
| Feature | ESM (Eggshell Membrane) | C-PDRN (Cosmetic PDRN) |
|---|---|---|
| Mode of Action | Provides collagen, elastin, hyaluronic acid, amino acids — structural building blocks | Works at DNA/nucleotide level to stimulate repair and renewal |
| Penetration | Hydrolyzed peptides penetrate skin; oral supplements absorbed systemically | Hydrolyzed for topical use; penetrates epidermis/upper dermis |
| Clinical Use | Proven in multiple human trials to improve skin elasticity, hydration, wrinkle reduction, and joint comfort | Best known in post-procedure soothing, skin recovery, texture improvement |
| Form | Oral + topical (inside-out approach) | Topical (serums, creams) |
| Sustainability | Upcycled from eggshell waste, eco-friendly and sustainable | Derived from salmon DNA |
| Anti-Aging Power | Long-term structural support, holistic anti-aging inside and out | Fast repair, soothing, cosmetic anti-aging boost |
Why We Chose Eggshell Membrane
At Vicky en France, our philosophy is Feel Good. Look Good. Do Good.
While C-PDRN is exciting in topical cosmetics, it remains limited to surface repair. ESM goes further — nourishing the body with the proteins and peptides it naturally loses, while helping the planet by upcycling a valuable resource.
This is why our hero ingredient is refined French-sourced eggshell membrane, featured across our range:
- C’est la Chic(k): handmade collagen scrub soap in an egg shape
- C’est la BERRY: collagen + HA age-defying super jelly
- ÔROJI Le Masque: lifting peel-off mask with collagen and ESM
Final Takeaway
- C-PDRN: Great for quick repair, clinical feel, topical rejuvenation.
- ESM: Holistic, sustainable, proven for daily anti-aging inside and out.
When it comes to true longevity beauty and health, eggshell membrane is the ingredient that doesn’t just care for your skin — it supports your whole self, and even our planet.
✨ Celebrate life. Celebrate skin. Celebrate the future of beauty with us.
